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6. Keatinge-Clay AT (2012) The constructions of style I polyketide synthases. Nat Prod Rep 29(10):1050?073. 7. Bravo-Rodriguez K, et al. (2015) Substrate adaptability of a mutated acyltransferase area and implications for polyketide biosynthesis. Chem Biol 22(11): 1425?430. eight. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A combined experimental and theoretical method of substrate recognition of the polyketide synthase. ACS Chem Biol eight(2):443?fifty. 9. McDaniel R, et al. (1999) Various genetic modifications of the erythromycin polyketide synthase to provide a library of novel "unnatural" natural items. Proc Natl Acad Sci United states of america ninety six(5):1846?851. 10. Walker MC, et al. (2013) Expanding the fluorine chemistry of dwelling devices utilizing engineered polyketide synthase pathways. Ng a one hundred?oil-immersion aim within a Zeiss Axioplan 2 fluorescence microscope with Science 341(6150):1089?094. 11. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative assessment of the substrate specificity of trans- compared to cis-acyltransferases of assembly line polyketide synthases. Biochemistry fifty three(23):3796?806.12. Koryakina I, et al. (2013) Poly unique trans-acyltransferase equipment disclosed by using engineered acyl-CoA synthetases. ACS Chem Biol eight(one):two hundred?08. Controls, the sensitivity at ninety five specificity of your "OR" rule combination of thirteen. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Assessing the equilibrium involving proteinprotein interactions and enzyme-substrate interactions in the channeling of intermediates concerning polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. fourteen. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender device and acyl carrier protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains with the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(9):3067?074. 15. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of the modular polyketide synthase toward natural and non-natural extender models. Org Biomol Chem eleven(27):4449?458. 16. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) Initial biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep three:3156. seventeen. Jenner M, et al.Try experiments. This work was funded through the generous support of a Nationwide Institutes of Wellness New Innovator Award one DP2 OD008696. O.A. and B.W.T. also admit the aid of a Nationwide Institutes of Overall health Training Grant T32 GMO66698. The faculty of Chemistry NMR Grants in the College of California, Berkeley is supported in part by National Institutes of Overall health Grants 1S10RR023679-01 and S10 RR16634-01.one. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium overview. Nat Prod Rep 18(4):380?16. 2. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Structure and system with the 6-deoxyerythronolide B synthase. Annu Rev Biochem seventy six:195?21. three. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface 10(eighty five):20130297. 4. Ray L, Moore BS (2016) Recent advances in the biosynthesis of bizarre polyketide synthase substrates. Nat Prod Rep 33(2):one hundred fifty?61. 5. Hagmann WK (2008) The many roles for fluorine in medicinal chemistry. J Med Chem 51(15):4359?369.