Check out experiments. This function was funded by the generous support of

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Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) Initial biosynthetic pathway of RRx-001 In stock 1-hepten-3-one in Iporangaia pustulosa (Opiliones). This function was funded because of the generous help of a Countrywide Institutes of Wellbeing New Innovator Award 1 DP2 OD008696. O.A. and B.W.T. also admit the guidance of a National Institutes of Health and fitness Schooling Grant T32 GMO66698. The faculty of Chemistry NMR Grants for the University of California, Berkeley is supported partly by Nationwide Institutes of Health Grants 1S10RR023679-01 and S10 RR16634-01.one. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium review. Nat Prod Rep eighteen(four):380?16. two. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Composition and system of the 6-deoxyerythronolide B synthase. Annu Rev Biochem 76:195?21. three. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface 10(85):20130297. four. Ray L, Moore BS (2016) Latest advancements during the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep 33(2):one hundred fifty?sixty one. 5. Hagmann WK (2008) The various roles for fluorine in medicinal chemistry. J Med Chem 51(fifteen):4359?369. 6. Keatinge-Clay AT (2012) The structures of form I polyketide synthases. Nat Prod Rep 29(ten):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate versatility of a mutated acyltransferase domain and implications for polyketide biosynthesis. Chem Biol 22(11): 1425?430. 8. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A put together experimental and theoretical method of substrate recognition of the polyketide synthase. ACS Chem Biol eight(2):443?fifty. 9. McDaniel R, et al. (1999) Multiple genetic modifications from the erythromycin polyketide synthase to produce a library of novel "unnatural" normal products. Proc Natl Acad Sci United states of america 96(5):1846?851. 10. Walker MC, et al. (2013) Increasing the fluorine chemistry of living systems making use of engineered polyketide synthase pathways. Science 341(6150):1089?094. eleven. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative evaluation from the substrate specificity of trans- vs . cis-acyltransferases of assembly line polyketide synthases. Biochemistry fifty three(23):3796?806.12. Koryakina I, et al. (2013) Poly precise trans-acyltransferase equipment exposed by using engineered acyl-CoA synthetases. ACS Chem Biol 8(one):two hundred?08. 13. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Assessing the balance between proteinprotein interactions and enzyme-substrate interactions inside the channeling of intermediates among polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. [1] fourteen. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender unit and acyl provider protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains with the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. fifteen. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of a modular polyketide synthase in the direction of pure and non-natural extender models. Org Biomol Chem eleven(27):4449?458. 16. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) First biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones).