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Koryakina I, SB-649868 manufacturer McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of a modular polyketide synthase in direction of organic and non-natural extender units. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) First biosynthetic pathway of SB-431542 Biological Activity 1-hepten-3-one in Iporangaia pustulosa (Opiliones). The faculty of Chemistry NMR Grants on the College of California, Berkeley is supported in part by Nationwide Institutes of Well being Grants 1S10RR023679-01 and S10 RR16634-01.1. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium review. Nat Prod Rep 18(4):380?sixteen. 2. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Framework and system with the 6-deoxyerythronolide B synthase. Annu Rev Biochem seventy six:195?21. 3. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface 10(eighty five):20130297. four. Ray L, Moore BS (2016) The latest developments during the biosynthesis of bizarre polyketide synthase substrates. Nat Prod Rep 33(two):one hundred fifty?sixty one. five. Hagmann WK (2008) The many roles for fluorine in medicinal chemistry. J Med Chem fifty one(15):4359?369. 6. Keatinge-Clay AT (2012) The constructions of sort I polyketide synthases. Nat Prod Rep 29(10):1050?073. 7. Bravo-Rodriguez K, et al. (2015) Substrate flexibility of a mutated acyltransferase area and implications for polyketide biosynthesis. Chem Biol 22(11): 1425?430. 8. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A mixed experimental and theoretical approach to substrate recognition of a polyketide synthase. ACS Chem Biol 8(two):443?50. nine. McDaniel R, et al. (1999) A number of genetic modifications on the erythromycin polyketide synthase to provide a library of novel "unnatural" pure merchandise. Proc Natl Acad Sci United states ninety six(five):1846?851. 10. Walker MC, et al. (2013) Increasing the fluorine chemistry of living units making use of engineered polyketide synthase pathways. Science 341(6150):1089?094. eleven. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative analysis in the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases. Biochemistry 53(23):3796?806.12. Koryakina I, et al. (2013) Poly particular trans-acyltransferase equipment uncovered through engineered acyl-CoA synthetases. ACS Chem Biol 8(one):two hundred?08. 13. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Evaluating the equilibrium between proteinprotein interactions and enzyme-substrate interactions during the channeling of intermediates in between polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. 14. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender device and acyl provider protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains of your 6-deoxyerythronolide B synthase. J Am Chem Soc 128(9):3067?074. 15. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of a modular polyketide synthase to natural and non-natural extender units. Org Biomol Chem eleven(27):4449?458. 16. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) First biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep three:3156. seventeen. Jenner M, et al. (2015) Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases. Angew Chem Int Ed Engl fifty four(six): 1817?821.