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and B.W.T. also admit the assist of a Nationwide Institutes of Health PF-02341066 Biological Activity Coaching Grant T32 GMO66698. The school of Chemistry NMR Grants for the College of California, Berkeley is supported in part by National Institutes of Health Grants 1S10RR023679-01 and S10 RR16634-01.1. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium review. Nat Prod Rep eighteen(four):380?sixteen. 2. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Composition and system of your 6-deoxyerythronolide B synthase. Annu Rev Biochem 76:195?21. 3. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface ten(85):20130297. four. Ray L, Moore BS (2016) Modern developments in the biosynthesis of surprising polyketide synthase substrates. Nat Prod Rep 33(2):150?sixty one. 5. Hagmann WK (2008) The numerous roles for fluorine in medicinal chemistry. J Med Chem 51(15):4359?369. six. Keatinge-Clay AT (2012) The constructions of type I polyketide synthases. Nat Prod Rep 29(ten):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate flexibility of the mutated acyltransferase domain and implications for polyketide biosynthesis. Chem Biol 22(eleven): 1425?430. eight. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A mixed experimental and theoretical approach to substrate Cariprazine Neuronal Signaling recognition of a polyketide synthase. ACS Chem Biol eight(2):443?50. nine. McDaniel R, et al. (1999) Multiple genetic modifications on the erythromycin polyketide synthase to make a library of novel "unnatural" normal solutions. Proc Natl Acad Sci United states of america 96(five):1846?851. ten. Walker MC, et al. (2013) Growing the fluorine chemistry of dwelling units making use of engineered polyketide synthase pathways. PF-06463922 Biological Activity Science 341(6150):1089?094. eleven. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative analysis on the substrate specificity of trans- vs . cis-acyltransferases of assembly line polyketide synthases. Biochemistry fifty three(23):3796?806.twelve. Koryakina I, et al. (2013) Poly specific trans-acyltransferase machinery uncovered by way of engineered acyl-CoA synthetases. ACS Chem Biol 8(1):two hundred?08. 13. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Examining the equilibrium concerning proteinprotein interactions and enzyme-substrate interactions within the channeling of intermediates in between polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. 14. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) PF-06651600 SDS extender unit and acyl provider protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains of your 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. fifteen. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of a modular polyketide synthase in the direction of normal and non-natural extender units. Org Biomol Chem 11(27):4449?458. sixteen. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) Initially biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep 3:3156. 17. Jenner M, et al. (2015) Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases. Angew Chem Int Ed Engl 54(six): 1817?821.