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Ray L, Moore BS (2016) Latest improvements during the biosynthesis of unusual polyketide He CNS and sometimes localizes to synapses PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender unit and acyl provider protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. fifteen. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of a modular polyketide synthase in direction of all-natural and non-natural extender models. Org Biomol Chem eleven(27):4449?458. sixteen. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) Initially biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep three:3156. Wong FT, Jin X, Mathews II, Cane DE, Khosla C (2011) Framework and mechanism on the trans-acting acyltransferase with the disorazole synthase. Biochemistry fifty(thirty): 6539?548. 19. Wong FT, Chen AY, Cane DE, Khosla C (2010) Protein-protein recognition between acyltransferases and acyl carri.Consider experiments. This do the job was funded because of the generous assist of the National Institutes of Wellbeing New Innovator Award one DP2 OD008696. O.A. and B.W.T. also accept the assistance of the National Institutes of Wellness Teaching Grant T32 GMO66698. The school of Chemistry NMR Grants for the University of California, Berkeley is supported partly by Countrywide Institutes of Wellbeing Grants 1S10RR023679-01 and S10 RR16634-01.one. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium overview. Nat Prod Rep eighteen(four):380?16. two. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Structure and mechanism from the 6-deoxyerythronolide B synthase. Annu Rev Biochem 76:195?21. three. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface ten(85):20130297. 4. Ray L, Moore BS (2016) Latest advancements while in the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep 33(2):a hundred and fifty?61. five. Hagmann WK (2008) The numerous roles for fluorine in medicinal chemistry. J Med Chem 51(fifteen):4359?369. 6. Keatinge-Clay AT (2012) The structures of style I polyketide synthases. Nat Prod Rep 29(10):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate overall flexibility of the mutated acyltransferase domain and implications for polyketide biosynthesis. Chem Biol 22(eleven): 1425?430. eight. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A put Substrate for this module (seventeen). In WT Mod3TE, where by chain extension together experimental and theoretical method of substrate recognition of a polyketide synthase. ACS Chem Biol eight(2):443?fifty. nine. McDaniel R, et al. (1999) Numerous genetic modifications of your erythromycin polyketide synthase to generate a library of novel "unnatural" all-natural products and solutions. Proc Natl Acad Sci United states of america 96(5):1846?851. ten. Walker MC, et al. (2013) Expanding the fluorine chemistry of dwelling programs using engineered polyketide synthase pathways. Science 341(6150):1089?094. eleven. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative examination of the substrate specificity of trans- as opposed to cis-acyltransferases of assembly line polyketide synthases. Biochemistry 53(23):3796?806.twelve. Koryakina I, et al. (2013) Poly precise trans-acyltransferase machinery discovered via engineered acyl-CoA synthetases.