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Ray L, Moore BS (2016) Current developments while in the biosynthesis of surprising polyketide PMA Purity & Documentation synthase substrates. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender device and acyl provider protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains from the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. 15. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of the modular polyketide synthase towards purely natural and non-natural extender models. Org Biomol Chem eleven(27):4449?458. 16. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) 1st biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep three:3156. seventeen. Jenner M, et al. (2015) Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases. Angew Chem Int Ed Engl fifty four(6): 1817?821. 18.Attempt experiments. This function was funded with the generous support of a National Institutes of Overall health New Innovator Award one DP2 OD008696. O.A. and B.W.T. also acknowledge the aid of the Countrywide Institutes of Health Training Grant T32 GMO66698. The school of Chemistry NMR Grants at the University of California, Berkeley is supported partly by Nationwide Institutes of Overall health Grants 1S10RR023679-01 and S10 RR16634-01.one. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium evaluate. Nat Prod Rep 18(4):380?sixteen. 2. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Framework and mechanism on the 6-deoxyerythronolide B synthase. Annu Rev Biochem 76:195?21. 3. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface ten(eighty five):20130297. four. Ray L, Moore BS (2016) Current advances in the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep 33(2):a hundred and fifty?sixty one. five. Hagmann WK (2008) The numerous roles for fluorine in medicinal chemistry. J Med Chem 51(fifteen):4359?369. 6. Keatinge-Clay AT (2012) The structures of kind I polyketide synthases. Nat Prod Rep 29(10):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate flexibility of the mutated acyltransferase domain and implications for polyketide biosynthesis. Chem Biol 22(11): 1425?430. 8. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A blended experimental and theoretical approach to substrate recognition of a polyketide synthase. ACS Chem Biol 8(two):443?50. 9. McDaniel R, et al. (1999) Various genetic modifications with the erythromycin polyketide synthase to provide a library of novel "unnatural" normal products and solutions. Proc Natl Acad Sci Usa ninety six(5):1846?851. ten. Walker MC, et al. (2013) Growing the fluorine chemistry of Kainic acid supplier residing methods utilizing engineered polyketide synthase pathways. Science 341(6150):1089?094. 11. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative examination in the substrate specificity of trans- vs . cis-acyltransferases of assembly line polyketide synthases. Biochemistry 53(23):3796?806.twelve. Koryakina I, et al. (2013) Poly precise trans-acyltransferase equipment disclosed via engineered acyl-CoA synthetases. ACS Chem Biol 8(one):two hundred?08. thirteen. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Assessing the balance amongst proteinprotein interactions and enzyme-substrate interactions during the channeling of intermediates in between polyketide synthase modules. J Am Chem Soc 123(27): 6465?474.