Lantation. We conclude that our method allows investigation of changes in

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In combination with histological and molecular iological examinations, our method could give new insights into processing of mechanically evoked development of inflammation, apoptosis, necrosis or physiological reactions (for example, Omorbidity was Omorbidity was present. In 28 individuals (12 ), 1 or more RBC transfusions ended up present. In 28 individuals (12 ), 1 or more RBC transfusions ended up muscle fatigue). To our knowledge, this isTable 1 (abstract P322) Data from T24 through T48 Hemodynamics PubMed ID: MAP (mmHg) NPT No PubMed ID: NPT 65 ?1.3 59 ?2.Pthe fist setup that allows repeated measurement of mechanical tissue properties at the same sample. We therefore further conclude that with our method the number of animal experiments could be reduced. Reference 1. Schumann S, Stahl CA, M ler K, et al.: Contact-free determination of material characteristics using a newly developed pressure-operated strain-applying bioreactor. J Biomed Mater Res B Appl Biomater, in press.P322 Negative pressure therapy improved outcome in a clinically applicable abdominal compartment syndrome porcine modelS Albert1, B Kubiak1, G Hutchinson2, K Norbury2, G Nieman1 1SUNY Upstate Medical University, Syracuse, NY, USA; 2KCI USA Inc., San Antonio, TX, USA Critical Care 2008, 12(Suppl 2):P322 (doi: 10.1186/cc6543) Introduction Abdominal compartment syndrome (ACS) is manifested by elevated intra-abdominal pressures (IAP) and associated hemodynamic, lung, or renal dysfunction. ACS may develop in trauma, pancreatitis, or burn patients. Abdominal closure after laparotomy, using negative pressure therapy (NPT) via a reticulated open-cell foam-based dressing, provides indirect negative pressure to the abdominal wall and viscera. We hypothesize that NPT improves hemodynamic, lung, and renal function as compared with a dressing-covered open abdomen without NPT. Methods Pigs (25?7 kg) were anesthetized and ventilated. After laparotomy, the superior mesenteric artery was occluded for 30 minutes. The cecum was perforated and a fecal clot was created to induce severe sepsis. Animals received isotonic fluid resuscitation titrated to mean arterial pressure (MAP) > 60 mmHg.Lung function Plateau pressure (cmH2O) 19 ?0.46 23 ?1.Intestinal edema Bladder pressure (cmH2O) 11 ?1.33 18 ?1.14 Wet/dry 5.99 ?0.20 8.22 ?0.Renal function Creatine (mg/dl) 1.08 ?0.06 1.7 ?0.22 Urine output (ml/hour) 135 ?17 45 ?Cardiac output (l/min) 3.00 ?0.08 1.70 ?0.SData are mean ?SE.