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Annu Rev PF-06651600 site Biochem seventy six:195?21. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Assessing the equilibrium concerning proteinprotein interactions and enzyme-substrate interactions inside the channeling of intermediates in between polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. 14. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender unit and acyl carrier protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains in the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. 15. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of the modular polyketide synthase to pure and non-natural extender models. Org Biomol Chem 11(27):4449?458. 16. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) Initially biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep three:3156. seventeen. Jenner M, et al. (2015) Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.Attempt experiments. This work was funded because of the generous help of a Countrywide Institutes of Wellness New Innovator Award 1 DP2 OD008696. O.A. and B.W.T. also admit the guidance of a Nationwide Institutes of Health Training Grant T32 GMO66698. The school of Chemistry NMR Grants for the University of California, Berkeley is supported partly by Countrywide Institutes of PMA Protocol overall health Grants 1S10RR023679-01 and S10 RR16634-01.1. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium assessment. Nat Prod Rep eighteen(4):380?sixteen. 2. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Composition and system of your 6-deoxyerythronolide B synthase. Annu Rev Biochem seventy six:195?21. three. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface ten(eighty five):20130297. 4. Ray L, Moore BS (2016) Latest advancements during the biosynthesis of surprising polyketide synthase substrates. Nat Prod Rep 33(2):one hundred fifty?61. five. Hagmann WK (2008) The many roles for fluorine in medicinal chemistry. J Med Chem fifty one(fifteen):4359?369. 6. Keatinge-Clay AT (2012) The structures of type I polyketide synthases. Nat Prod Rep 29(ten):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate overall flexibility of the mutated acyltransferase area and implications for polyketide biosynthesis. Chem Biol 22(11): 1425?430. eight. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A merged experimental and theoretical method of substrate recognition of the polyketide synthase. ACS Chem Biol 8(two):443?fifty. nine. McDaniel R, et al. (1999) Several genetic modifications of your erythromycin polyketide synthase to create a library of novel "unnatural" natural products. Proc Natl Acad Sci United states of america ninety six(five):1846?851. ten. Walker MC, et al. (2013) Increasing the fluorine chemistry of dwelling systems working with engineered polyketide synthase pathways. Science 341(6150):1089?094. eleven. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative examination in the substrate specificity of trans- vs . cis-acyltransferases of assembly line polyketide synthases. Biochemistry 53(23):3796?806.12. Koryakina I, et al.