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Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate PF-04447943 manufacturer specificity of assembly line polyketide Piperlongumine Autophagy synthases. J R Soc Interface ten(eighty five):20130297. 4. Ray L, Moore BS (2016) PF-06651600 supplier Modern improvements in the biosynthesis of surprising polyketide synthase substrates. Nat Prod Rep 33(2):a hundred and fifty?sixty one. 5. Hagmann WK (2008) The various roles for fluorine in medicinal chemistry. J Med Chem 51(fifteen):4359?369. 6. Keatinge-Clay AT (2012) The structures of form I polyketide synthases. Nat Prod Rep 29(10):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate versatility of a mutated acyltransferase area and implications for polyketide biosynthesis. Chem Biol 22(eleven): 1425?430. 8. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A merged experimental and theoretical approach to substrate recognition of the polyketide synthase. ACS Chem Biol 8(two):443?50. nine. McDaniel R, et al. (1999) Multiple genetic PF-02341066 MedChemExpress modifications on the erythromycin polyketide synthase to create a library of novel "unnatural" pure merchandise. Proc Natl Acad Sci Usa 96(5):1846?851. 10. Walker MC, et al. (2013) Increasing the fluorine chemistry of dwelling systems using engineered polyketide synthase pathways. Science 341(6150):1089?094. eleven. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative assessment of your substrate specificity of trans- compared to cis-acyltransferases of assembly line polyketide synthases. Biochemistry 53(23):3796?806.12. Koryakina I, et al. (2013) Poly particular trans-acyltransferase equipment revealed by using engineered acyl-CoA synthetases. ACS Chem Biol eight(1):200?08. thirteen. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Assessing the stability amongst proteinprotein interactions and enzyme-substrate interactions while in the channeling of intermediates in between polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. 14. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender device and acyl provider protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains in the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. fifteen. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of a modular polyketide synthase toward organic and non-natural extender models. Org Biomol Chem 11(27):4449?458. sixteen. Rocha DF, Wouters FC, Machado G, Marsaioli AJ (2013) Initial biosynthetic pathway of 1-hepten-3-one in Iporangaia pustulosa (Opiliones). Sci Rep 3:3156. 17. Jenner M, et al. (2015) Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases. Angew Chem Int Ed Engl fifty four(6): 1817?821. eighteen. Wong FT, Jin X, Mathews II, Cane DE, Khosla C (2011) Construction and system with the trans-acting acyltransferase with the disorazole synthase. Biochemistry fifty(30): 6539?548.Attempt experiments. This do the job was funded through the generous support of a Nationwide Institutes of Overall health New Innovator Award 1 DP2 OD008696. O.A. and B.W.T. also admit the help of a Countrywide Institutes of Overall health Instruction Grant T32 GMO66698. The faculty of Chemistry NMR Grants with the University of California, Berkeley is supported partially by Countrywide Institutes of Overall health Grants 1S10RR023679-01 and S10 RR16634-01.one.