Try out experiments. This function was funded from the generous help of

From Cypher Gate Wiki
Revision as of 01:55, 9 December 2019 by Robertfield83 (talk | contribs) (Created page with "(2013) Poly precise [https://www.medchemexpress.com/SB-431542.html SB-431542 supplier] trans-acyltransferase equipment discovered by way of engineered acyl-CoA synthetases. Wo...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search

(2013) Poly precise SB-431542 supplier trans-acyltransferase equipment discovered by way of engineered acyl-CoA synthetases. Wong FT, Jin X, mce site Mathews II, Cane DE, Khosla C (2011) Structure and system from the trans-acting acyltransferase with the disorazole synthase. Biochemistry fifty(30): 6539?548.Try experiments. This perform was funded via the generous assist of the National Institutes of Health New Innovator Award one DP2 OD008696. O.A. and B.W.T. also admit the help of the Countrywide Institutes of Health Teaching Grant T32 GMO66698. The school of Chemistry NMR Grants with the College of California, Berkeley is supported partly by Countrywide Institutes of Health Grants 1S10RR023679-01 and S10 RR16634-01.1. Staunton J, Weissman KJ (2001) Polyketide biosynthesis: A millennium assessment. Nat Prod Rep eighteen(4):380?16. two. Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE (2007) Framework and system in the 6-deoxyerythronolide B synthase. Annu Rev Biochem seventy six:195?21. 3. Dunn BJ, Khosla C (2013) Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface 10(eighty five):20130297. 4. Ray L, Moore BS (2016) Modern innovations inside the biosynthesis of bizarre polyketide synthase substrates. Nat Prod Rep 33(two):a hundred and fifty?61. five. Hagmann WK (2008) The many roles for fluorine in medicinal chemistry. J Med Chem 51(fifteen):4359?369. six. Keatinge-Clay AT (2012) The structures of variety I polyketide synthases. Nat Prod Rep 29(10):1050?073. seven. Bravo-Rodriguez K, et al. (2015) Substrate flexibility of a mutated acyltransferase area and implications for polyketide biosynthesis. Chem Biol 22(11): 1425?430. eight. Sundermann U, et al. (2013) Enzyme-directed mutasynthesis: A blended experimental and theoretical method of substrate recognition of the polyketide synthase. ACS Chem Biol eight(two):443?fifty. nine. McDaniel R, et al. (1999) Various genetic modifications of the erythromycin polyketide synthase to supply a library of novel "unnatural" pure products and solutions. Proc Natl Acad Sci United states of america 96(five):1846?851. 10. Walker MC, et al. (2013) Expanding the fluorine chemistry of living devices working with engineered polyketide synthase pathways. Science 341(6150):1089?094. 11. Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C (2014) Comparative evaluation of the substrate specificity of trans- vs . cis-acyltransferases of assembly line polyketide synthases. Biochemistry fifty three(23):3796?806.twelve. Koryakina I, et al. (2013) Poly distinct trans-acyltransferase equipment uncovered through engineered acyl-CoA synthetases. ACS Chem Biol eight(1):two hundred?08. thirteen. Wu N, Tsuji SY, Cane DE, Khosla C (2001) Examining the harmony involving proteinprotein interactions and enzyme-substrate interactions while in the channeling of intermediates between polyketide synthase modules. J Am Chem Soc 123(27): 6465?474. fourteen. Chen AY, Schnarr NA, Kim PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24107419 CY, Cane DE, Khosla C (2006) Extender unit and acyl carrier protein specificity PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23721119 of ketosynthase domains with the 6-deoxyerythronolide B synthase. J Am Chem Soc 128(nine):3067?074. fifteen. Koryakina I, McArthur JB, Draelos MM, Williams GJ (2013) Promiscuity of the modular polyketide synthase in direction of purely natural and non-natural extender units.